200 years from the first documented outbreak: Dying of cholera in the Near East during 2022 (recent data analysis)

After decades of decline, the fast-paced cholera outbreaks recently declared in Lebanon and Syria marked an unwelcome comeback in the Near East. Boosted by complex health emergencies, prolonged conflict, deteriorating economic conditions leading to poor water and sanitation systems, and climate change, cholera is now spreading at unprecedented levels in the region. Eight of 22 countries in the WHO Eastern Mediterranean Region have reported cases and deaths of cholera and acute watery diarrhea [2].

Impactful actions reflected in the GTFCC "Global Roadmap to 2030", including lessons from painful experiences like Haiti and Yemen, are critically needed. VIEWPOINTS Cholera is deadly, but it is also preventable through vaccines and access to safe water and sanitation. More severe cases are also easily treatable with oral rehydration or antibiotics. Unfortunately, many people do not have access to these simple interventions. A striking example is provided by Syria, where more than 10 years of conflict have decimated civilian infrastructure and services, including health care facilities, water and sanitation systems, and electricity grids. The United Nations (UN) estimates that two-thirds of Syria's water treatment plants, half of its pumping stations, and a third of its water towers have been damaged since 2011 [10].
Simultaneously, the International Coordinating Group (ICG) on vaccine provision is suspending the standard two-dose vaccination regimen in cholera outbreak response campaigns, resorting instead to a single-dose approach. The temporary use of a one-dose strategy due to a global shortage will allow more people to be vaccinated and provide them short-term protection [11]. While vaccines are a critical tool, they will not address the root causes for the increasing number and severity of outbreaks.
To sustainably end the increasing global transmission of cholera, the Global Task Force on Cholera Control (GTF-CC), a partnership of more than 50 non-governmental organizations (NGOs), academic institutions, and UN agencies [12], launched the "The Global Roadmap to 2030" in 2017. The roadmap aims for a 90% reduction in cholera deaths and cholera elimination in 20 countries by 2030 [13]. Among the proposed interventions, WASH provides the long-term solution, while risk communication and community engagement (RCCE) is at the core of the strategy. Cholera can be prevented with access to safe water and sanitation. As clearly shown by COVID-19 and the Ebola experience in West Africa during 2014/2015, RCCE is probably the most powerful and cost-effective tool for protecting health care workers and populations. However, providing technical guidance to ensure proper clinical management practices, infection prevention and control, cholera testing protocols and surveillance systems remains critical. The total cost is estimated at US$11 annually per person at risk, with a return to investment ratio of 10 to 1 [14].
These past lessons are learned from painful experiences from contexts ranging from Haiti to Yemen [15][16][17]. National governments, alongside humanitarian and development actors heed these lessons, both to save lives and precious resources. Yet despite our knowledge on what works, case fatality rates during recent outbreaks in the Near East seem higher than usual. This is in part due to the sizes of the outbreaks: the larger the outbreak, the worse the outcomes. Climate events have also had an impact, as has the fact that outbreaks occurred in conflict-affected areas. Health resources have also been repurposed during the COVID-19 pandemic. These and other factors have played a role, while critical investments to fund the "The Global Roadmap to 2030" were not realized.
What would John Snow say, one and a half century after he implemented WASH interventions to stop cholera transmission in London, if he heard that people in 2022 were still dying of cholera? Quick and impactful action is needed.

Photo: Streets of Beirut, Lebanon, at night. From Saverio Bellizzi's own collection.
Funding: None reported.
Authorship contributions: All authors equally contributed to conceiving, preparing, and finalizing the manuscript.

Disclosure of interest:
The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests.